Journal article
Varicella-Zoster virus ORF9 Is an antagonist of the DNA sensor cGAS
- Abstract:
-
Varicella-Zoster virus (VZV) causes chickenpox and shingles. Although infection is associated with severe morbidity in some individuals, the molecular mechanisms that determine innate immune responses remain poorly defined. We found that the cGAS/STING DNA sensing pathway was critically required for type I interferon (IFN) induction in response to VZV infection. Viral gene overexpression screening identified the essential VZV tegument protein ORF9 as a novel antagonist of DNA sensing via cGAS...
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- Publication status:
- Not published
- Peer review status:
- Not peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Cold Spring Harbor Laboratory Publisher's website
- Journal:
- bioRxiv Journal website
- DOI:
Item Description
- Language:
- English
- Pubs id:
-
1087407
- Local pid:
- pubs:1087407
- Deposit date:
- 2020-05-22
Terms of use
- Copyright holder:
- Hertzog et al.
- Rights statement:
- The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
- Notes:
- This is the author's original version of the paper available online from bioRxiv at: https://doi.org/10.1101/2020.02.11.943415
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