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Journal article

Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility.

Abstract:

The Y-chromosome is frequently lost in hematopoietic cells, representing the most common somatic mutation in men. However, the mechanisms regulating mosaic loss of chromosome-Y (mLOY), and its clinical relevance, are unknown. Using genotype array intensity data and sequence reads in 85,542 men, we identify 19 genomic regions (P<5x10-8) associated with mLOY. Cumulatively, these loci also predicted X-chromosome loss in women (N=96,123, P=4x10-6). Additional epigenome-wide methylation anal...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/ng.3821

Authors


Wright, DJ More by this author
Kerrison, ND More by this author
Cardona, A More by this author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
49
Issue:
5
Pages:
674-679
Publication date:
2017-03-05
Acceptance date:
2017-02-26
DOI:
ISSN:
1061-4036 and 1546-1718
Pubs id:
pubs:687907
URN:
uri:cf28dac2-a0b4-465d-a1a9-be7f3e69b57c
UUID:
uuid:cf28dac2-a0b4-465d-a1a9-be7f3e69b57c
Local pid:
pubs:687907
Language:
English
Keywords:

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