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Regulation of endothelial nitric-oxide synthase (NOS) S-glutathionylation by neuronal NOS: evidence of a functional interaction between myocardial constitutive NOS isoforms.

Abstract:

Background

PWhether neuronal nitric-oxide synthase (nNOS) plays a role in the endothelial NOS (eNOS)-dependent negative inotropic effect of β3-adrenergic stimulation remains to be established.

Results

nNOS knock-out or inhibition leads to increased superoxide production, eNOS uncoupling, and abrogation of β3-adrenergic responses.

Conclusion

Disabling nNOS disrupts eNOS function and downstream signaling.

Significance

nNOS plays a cru...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1074/jbc.m112.412031

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
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Funding agency for:
Carnicer, R
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Funding agency for:
Crabtree, MJ
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Funding agency for:
Casadei, B
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Publisher:
American Society of Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
287
Issue:
52
Pages:
43665-43673
Publication date:
2012-10-05
Acceptance date:
2012-10-19
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:cf26ec82-a4cd-4196-b108-a4ff72044147
Source identifiers:
356219
Local pid:
pubs:356219

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