Human colonic intraepithelial lymphocytes suppress in vitro immunoglobulin synthesis by autologous peripheral blood lymphocytes and lamina propria lymphocytes.

Journal article

Human colonic intraepithelial lymphocytes have been shown to suppress the proliferation of autologous lamina propria lymphocytes and allogeneic peripheral blood mononuclear cells. This study has shown that, in vitro, intraepithelial lymphocytes suppress IgA and total immunoglobulin synthesis (but not IgG or IgM production) by autologous peripheral blood and lamina propria lymphocytes. This down regulation of IgA production is mediated by a soluble factor secreted by the intraepithelial lympho...

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Authors: Sachdev, G; Dalton, H; Hoang, P; DiPaolo, M; Crotty, B

• Publication status: Published
• Journal: Gut
• Volume: 34
• Issue: 2
• Pages: 257-263
• Publication date: 1993-02-01
• DOI: 10.1136/gut.34.2.257
• EISSN: 1468-3288
• ISSN: 0017-5749
• Language: English
• Keywords: T-Lymphocytes; Adolescent; Colon; Down-Regulation; Inflammatory Bowel Diseases; Aged; Epithelium; Cell Division; Immunoglobulins; Female; Middle Aged; Immune Tolerance; Humans; Immunoglobulin M; Immunoglobulin A; Adult; Cells, Cultured; Immunoglobulin G; Male