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Human colonic intraepithelial lymphocytes suppress in vitro immunoglobulin synthesis by autologous peripheral blood lymphocytes and lamina propria lymphocytes.

Abstract:

Human colonic intraepithelial lymphocytes have been shown to suppress the proliferation of autologous lamina propria lymphocytes and allogeneic peripheral blood mononuclear cells. This study has shown that, in vitro, intraepithelial lymphocytes suppress IgA and total immunoglobulin synthesis (but not IgG or IgM production) by autologous peripheral blood and lamina propria lymphocytes. This down regulation of IgA production is mediated by a soluble factor secreted by the intraepithelial lympho...

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Publication status:
Published

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Publisher copy:
10.1136/gut.34.2.257

Authors


Journal:
Gut More from this journal
Volume:
34
Issue:
2
Pages:
257-263
Publication date:
1993-02-01
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
Language:
English
Keywords:
Pubs id:
pubs:135346
UUID:
uuid:cefde9a4-b57a-47d4-8459-899a98b19ff4
Local pid:
pubs:135346
Source identifiers:
135346
Deposit date:
2012-12-19

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