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Hippocampal synaptic plasticity, spatial memory and anxiety.

Abstract:
Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.
Publication status:
Published

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Publisher copy:
10.1038/nrn3677

Authors


Bannerman, DM More by this author
Sprengel, R More by this author
Sanderson, DJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
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Journal:
Nature reviews. Neuroscience
Volume:
15
Issue:
3
Pages:
181-192
Publication date:
2014-03-05
DOI:
EISSN:
1471-0048
ISSN:
1471-003X
URN:
uuid:cece2486-3c2e-43f8-93e9-ef1d5925eb5b
Source identifiers:
449142
Local pid:
pubs:449142

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