Hippocampal synaptic plasticity, spatial memory and anxiety.

Journal article

Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.

Authors: Bannerman, D; Sprengel, R; Sanderson, D; McHugh, S; Rawlins, J

• Publication status: Published
• Journal: Nature reviews. Neuroscience
• Volume: 15
• Issue: 3
• Pages: 181-192
• Publication date: 2014-03-01
• DOI: 10.1038/nrn3677
• EISSN: 1471-0048
• ISSN: 1471-003X
• Language: English
• Keywords: Hippocampus; Anxiety; Synaptic Transmission; Mice, Knockout; Synapses; Receptors, N-Methyl-D-Aspartate; Behavior, Animal; Mice; Memory; Space Perception; Neuronal Plasticity; Animals