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Journal article : Review

Advances in oligonucleotide drug delivery

Abstract:

Oligonucleotides can be used to modulate gene expression via a range of processes including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation, non-coding RNA inhibition, gene activation and programmed gene editing. As such, these molecules have potential therapeutic applications for myriad indications, with several oligonucleotide drugs recently gaining approval. However, despite recent technological advances, achieving efficient oligonucleotide delivery, particularly...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41573-020-0075-7

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
ORCID:
0000-0002-3313-7631
More by this author
Role:
Author
ORCID:
0000-0003-4255-0492
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
ORCID:
0000-0002-5436-6011
Publisher:
Springer Nature
Journal:
Nature Reviews Drug Discovery More from this journal
Volume:
19
Issue:
10
Pages:
673-694
Place of publication:
England
Publication date:
2020-08-11
Acceptance date:
2020-06-24
DOI:
EISSN:
1474-1784
ISSN:
1474-1776
Pmid:
32782413
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1126259
Local pid:
pubs:1126259
Deposit date:
2021-06-18

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