Journal article : Review
Advances in oligonucleotide drug delivery
- Abstract:
-
Oligonucleotides can be used to modulate gene expression via a range of processes including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation, non-coding RNA inhibition, gene activation and programmed gene editing. As such, these molecules have potential therapeutic applications for myriad indications, with several oligonucleotide drugs recently gaining approval. However, despite recent technological advances, achieving efficient oligonucleotide delivery, particularly...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Reviews Drug Discovery Journal website
- Volume:
- 19
- Issue:
- 10
- Pages:
- 673-694
- Place of publication:
- England
- Publication date:
- 2020-08-11
- Acceptance date:
- 2020-06-24
- DOI:
- EISSN:
-
1474-1784
- ISSN:
-
1474-1776
- Pmid:
-
32782413
Item Description
- Language:
- English
- Keywords:
- Subtype:
- Review
- Pubs id:
-
1126259
- Local pid:
- pubs:1126259
- Deposit date:
- 2021-06-18
Terms of use
- Copyright holder:
- Springer Nature Limited
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2020, Springer Nature Limited
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