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Designing candidate gene and genome-wide case-control association studies.

Abstract:

This protocol describes how to appropriately design a genetic association case-control study, either focusing on a candidate gene (CG) or region or implementing a genome-wide approach. The steps described involve: (i) defining the case phenotype in adequate detail; (ii) checking the heritability of the disease in question; (iii) considering whether a population-based study is the appropriate design for the research question; (iv) the appropriate selection of controls; (v) sample size calculat...

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Publication status:
Published

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Publisher copy:
10.1038/nprot.2007.366

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Nature protocols More from this journal
Volume:
2
Issue:
10
Pages:
2492-2501
Publication date:
2007-01-01
DOI:
EISSN:
1750-2799
ISSN:
1754-2189
Language:
English
Keywords:
Pubs id:
pubs:34013
UUID:
uuid:ceaede54-6a9d-4dc7-9edc-0c2e484544f3
Local pid:
pubs:34013
Source identifiers:
34013
Deposit date:
2012-12-19

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