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An overexpression screen of Toxoplasma gondii Rab-GTPases reveals distinct transport routes to the micronemes

Abstract:

The basic organisation of the endomembrane system is conserved in all eukaryotes and comparative genome analyses provides compelling evidence that the endomembrane system of the last common eukaryotic ancestor (LCEA) is complex with many genes required for regulated traffic being present. Although apicomplexan parasites, causative agents of severe human and animal diseases, appear to have only a basic set of trafficking factors such as Rab-GTPases, they evolved unique secretory organelles (mi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.ppat.1003213

Authors


Rittweger, E More by this author
Flammer, H More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
9
Issue:
3
Pages:
e1003213
Publication date:
2013-03-07
Acceptance date:
2013-01-10
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:ceae75cc-99e6-461f-83b6-b41789c1ceab
Source identifiers:
396233
Local pid:
pubs:396233

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