Th17 cells induce a distinct graft rejection response that does not require IL-17A.

Journal article

IL-17A-producing helper T (Th17) cells have been implicated in the pathogenesis of autoimmune disease, inflammatory bowel disease and graft rejection, however the mechanisms by which they cause tissue damage remain ill-defined. We examined what damage Th17 cell lines could inflict on allogeneic skin grafts in the absence of other adaptive lymphocytes. CD4(+) Th17 cell lines were generated from two TCR transgenic mouse strains, A1(M).RAG1(-/-) and Marilyn, each monospecific for the male anti...

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Authors: Agorogiannis, E; Regateiro, F; Howie, D; Waldmann, H; Cobbold, S

• Publication status: Published
• Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
• Volume: 12
• Issue: 4
• Pages: 835-845
• Publication date: 2012-04-01
• DOI: 10.1111/j.1600-6143.2011.03971.x
• EISSN: 1600-6143
• ISSN: 1600-6135
• Language: English
• Keywords: Mice, Inbred CBA; Th17 Cells; Cells, Cultured; Mice, Knockout; CD4-Positive T-Lymphocytes; Animals; Skin Transplantation; Chromatin Immunoprecipitation; Mice; Mice, Inbred C57BL; Female; Male; Adoptive Transfer; Lymphopenia; Interferon-gamma; Neutrophil Infiltration; Graft Rejection; Interleukin-17