Journal article
HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C
- Abstract:
-
Mechanical force-induced conformational changes in proteins underpin a variety of physiological functions, typified in muscle contractile machinery. Mutations in the actin-binding protein filamin C (FLNC) are linked to musculoskeletal pathologies characterized by altered biomechanical properties and sometimes aggregates. HspB1, an abundant molecular chaperone, is prevalent in striated muscle where it is phosphorylated in response to cues including mechanical stress. We report the interaction ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Advances Journal website
- Volume:
- 5
- Issue:
- 5
- Article number:
- eaav8421
- Publication date:
- 2019-05-22
- Acceptance date:
- 2019-04-16
- DOI:
- EISSN:
-
2375-2548
- Pmid:
-
31131323
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1003255
- UUID:
-
uuid:cea83cfa-0594-47bb-82f3-ddfe457b0bc3
- Local pid:
- pubs:1003255
- Source identifiers:
-
1003255
- Deposit date:
- 2019-05-29
Terms of use
- Copyright holder:
- Collier et al
- Copyright date:
- 2019
- Notes:
- © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S.Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
- Licence:
- CC Attribution (CC BY)
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