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BDNF val66met influences time to onset of levodopa induced dyskinesia in Parkinson's disease.

Abstract:

BACKGROUND: Levodopa induced dyskinesias (LID) are a common problem which ultimately limit the effective treatment of patients with Parkinson's disease (PD). There is accumulating evidence that LID develop due to abnormal synaptic plasticity, which is in turn influenced by the release of brain derived neurotrophic factor (BDNF). METHODS: The influence of a common functional polymorphism of the BDNF gene on the risk of developing dyskinesias in a large cohort of patients with PD (n = 315), wh...

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Publisher copy:
10.1136/jnnp.2008.154294

Authors


Foltynie, T More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Williams-Gray, CH More by this author
Edwards, MJ More by this author
Schneider, SA More by this author
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Journal:
Journal of neurology, neurosurgery, and psychiatry
Volume:
80
Issue:
2
Pages:
141-144
Publication date:
2009-02-05
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
URN:
uuid:cea3d85a-ba1b-46a0-8232-a016c15036bc
Source identifiers:
241187
Local pid:
pubs:241187

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