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Strain selection for generation of O-antigen-based glycoconjugate vaccines against invasive nontyphoidal salmonella disease

Abstract:

Nontyphoidal Salmonellae, principally S. Typhimurium and S. Enteritidis, are a major cause of invasive bloodstream infections in sub-Saharan Africa with no vaccine currently available. Conjugation of lipopolysaccharide O-antigen to a carrier protein constitutes a promising vaccination strategy. Here we describe a rational process to select the most appropriate isolates of Salmonella as source of O-antigen for developing a bivalent glycoconjugate vaccine. We screened a library of 30 S. Typhimu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0139847

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
10
Issue:
10
Pages:
e0139847
Chapter number:
ARTN e0139847
Publication date:
2015-10-07
Acceptance date:
2015-09-17
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:cea061f1-06f1-4d3a-a83a-33030d8446d0
Source identifiers:
571981
Local pid:
pubs:571981
Paper number:
10

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