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Journal article

Strain selection for generation of O-antigen-based glycoconjugate vaccines against invasive nontyphoidal salmonella disease

Abstract:

Nontyphoidal Salmonellae, principally S. Typhimurium and S. Enteritidis, are a major cause of invasive bloodstream infections in sub-Saharan Africa with no vaccine currently available. Conjugation of lipopolysaccharide O-antigen to a carrier protein constitutes a promising vaccination strategy. Here we describe a rational process to select the most appropriate isolates of Salmonella as source of O-antigen for developing a bivalent glycoconjugate vaccine. We screened a library of 30 S. Typhimu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0139847

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
10
Issue:
10
Pages:
e0139847
Publication date:
2015-10-07
Acceptance date:
2015-09-17
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
571981

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