- Abstract:
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Nontyphoidal Salmonellae, principally S. Typhimurium and S. Enteritidis, are a major cause of invasive bloodstream infections in sub-Saharan Africa with no vaccine currently available. Conjugation of lipopolysaccharide O-antigen to a carrier protein constitutes a promising vaccination strategy. Here we describe a rational process to select the most appropriate isolates of Salmonella as source of O-antigen for developing a bivalent glycoconjugate vaccine. We screened a library of 30 S. Typhimu...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.9MB)
-
- Publisher copy:
- 10.1371/journal.pone.0139847
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 10
- Issue:
- 10
- Pages:
- e0139847
- Chapter number:
- ARTN e0139847
- Publication date:
- 2015-10-07
- Acceptance date:
- 2015-09-17
- DOI:
- EISSN:
-
1932-6203
- ISSN:
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1932-6203
- URN:
-
uuid:cea061f1-06f1-4d3a-a83a-33030d8446d0
- Source identifiers:
-
571981
- Local pid:
- pubs:571981
- Paper number:
- 10
- Language:
- English
- Keywords:
- Copyright holder:
- Luisa Lanzilao et al.
- Copyright date:
- 2015
- Notes:
- This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Strain selection for generation of O-antigen-based glycoconjugate vaccines against invasive nontyphoidal salmonella disease
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