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Journal article

Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families.

Abstract:

The gene coding for the amyloid protein, a component of neuritic plaques found in brain tissue from patients with Alzheimer's disease, has been localized to chromosome 21, and neighbouring polymorphic DNA markers segregate with Alzheimer's disease in several large families. These data, and the association of Alzheimer's disease with Down's syndrome, suggest that overproduction of the amyloid protein, or production of an abnormal variant of the protein, may be the underlying pathological chang...

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Publication status:
Published

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Publisher copy:
10.1038/329153a0

Authors


Van Broeckhoven, C More by this author
Genthe, AM More by this author
Vandenberghe, A More by this author
Horsthemke, B More by this author
Backhovens, H More by this author
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Journal:
Nature
Volume:
329
Issue:
6135
Pages:
153-155
Publication date:
1987
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:ce8eba25-5e27-4992-877b-66b9865a0f57
Source identifiers:
440048
Local pid:
pubs:440048

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