Journal article
Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate
- Abstract:
-
The TREK subfamily of two-pore domain K+ (K2P) channels are inhibited by fluoxetine and its metabolite, norfluoxetine (NFx). Although not the principal targets of this antidepressant, TREK channel inhibition by NFx has provided important insights into the conformational changes associated with channel gating and highlighted the role of the selectivity filter in this process. However, despite the availability of TREK-2 crystal structures with NFx bound, the precise mechanisms underlying NFx in...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- Rockefeller University Press Publisher's website
- Journal:
- Journal of General Physiology Journal website
- Volume:
- 153
- Issue:
- 8
- Article number:
- e202012812
- Place of publication:
- United States
- Publication date:
- 2021-05-25
- Acceptance date:
- 2021-05-06
- DOI:
- EISSN:
-
1540-7748
- ISSN:
-
0022-1295
- Pmid:
-
34032848
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1179170
- Local pid:
- pubs:1179170
- Deposit date:
- 2021-07-22
Terms of use
- Copyright holder:
- Proks et al.
- Copyright date:
- 2021
- Rights statement:
- ©2021 Proks et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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