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Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.

Abstract:

Fibrosis is excessive scarring caused by the accumulation of extracellular matrix proteins and is a common end pathway in many chronic diseases. Endothelin-1 is a possible contributor to the persistent fibrotic phenotype of fibroblasts isolated from fibrotic lesions. In this report we used a specific dual endothelin A/B receptor antagonist, bosentan, to determine the role of endogenous endothelin signaling in maintaining the profibrotic phenotype of lung fibroblasts from scleroderma patients....

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Publication status:
Published

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Journal:
Matrix biology : journal of the International Society for Matrix Biology
Volume:
26
Issue:
8
Pages:
625-632
Publication date:
2007-10-05
DOI:
EISSN:
1569-1802
ISSN:
0945-053X
URN:
uuid:ce763c8b-fa2f-4e6d-b6aa-33d0fb385ccc
Source identifiers:
223513
Local pid:
pubs:223513

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