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Antibodies identified by cell-based assays in myasthenia gravis and associated diseases.

Abstract:

We have established cell-based assays for the improved detection of acetylcholine receptor (AChR) and muscle-specific kinase (MuSK) antibodies in myasthenia gravis. This approach has enabled us to demonstrate antibodies to "clustered" AChRs in patients who were previously AChR antibody negative and can also be used to distinguish between adult and fetal AChR antibodies in mothers of babies with arthrogryposis multiplex congenita. We summarize our recent evidence for the pathogenicity of MuSK ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Journal:
Annals of the New York Academy of Sciences
Volume:
1274
Issue:
1
Pages:
92-98
Publication date:
2012-12-01
DOI:
EISSN:
1749-6632
ISSN:
0077-8923
Source identifiers:
367787
Language:
English
Keywords:
Pubs id:
pubs:367787
UUID:
uuid:ce5ba6df-c7cc-4531-a38b-36dc0cf49c42
Local pid:
pubs:367787
Deposit date:
2013-11-16

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