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Copper is required for oncogenic BRAF signalling and tumorigenesis.

Abstract:

The BRAF kinase is mutated, typically Val 600→Glu (V600E), to induce an active oncogenic state in a large fraction of melanomas, thyroid cancers, hairy cell leukaemias and, to a smaller extent, a wide spectrum of other cancers. BRAF(V600E) phosphorylates and activates the MEK1 and MEK2 kinases, which in turn phosphorylate and activate the ERK1 and ERK2 kinases, stimulating the mitogen-activated protein kinase (MAPK) pathway to promote cancer. Targeting MEK1/2 is proving to be an important the...

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Publication status:
Published

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Publisher copy:
10.1038/nature13180

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Journal:
Nature
Volume:
509
Issue:
7501
Pages:
492-496
Publication date:
2014-05-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Source identifiers:
462180

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