Journal article
Copper is required for oncogenic BRAF signalling and tumorigenesis.
- Abstract:
-
The BRAF kinase is mutated, typically Val 600→Glu (V600E), to induce an active oncogenic state in a large fraction of melanomas, thyroid cancers, hairy cell leukaemias and, to a smaller extent, a wide spectrum of other cancers. BRAF(V600E) phosphorylates and activates the MEK1 and MEK2 kinases, which in turn phosphorylate and activate the ERK1 and ERK2 kinases, stimulating the mitogen-activated protein kinase (MAPK) pathway to promote cancer. Targeting MEK1/2 is proving to be an important the...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/nature13180
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Authors
Bibliographic Details
- Journal:
- Nature
- Volume:
- 509
- Issue:
- 7501
- Pages:
- 492-496
- Publication date:
- 2014-05-01
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- Source identifiers:
-
462180
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:462180
- UUID:
-
uuid:ce57e776-9c4a-41b9-8127-cc1f5fafc4c2
- Local pid:
- pubs:462180
- Deposit date:
- 2014-05-18
Terms of use
- Copyright date:
- 2014
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