Neurokinin-1 receptor antagonists as novel antidepressants: trials and tribulations.

Journal article

Based upon animal experiments and early clinical trials, neurokinin-1 receptor antagonists showed promise as novel antidepressants. Subsequently, however, more extensive clinical trials did not reveal evidence of efficacy in depression. The development of novel antidepressants will require a better understanding of the neural basis of antidepressant action in humans.

Authors: Hafizi, S; Chandra, P; Cowen, J

• Publication status: Published
• Journal: British journal of psychiatry : the journal of mental science
• Volume: 191
• Issue: 4
• Pages: 282-284
• Publication date: 2007-10-01
• DOI: 10.1192/bjp.bp.107.037879
• EISSN: 1472-1465
• ISSN: 0007-1250
• Language: English
• Keywords: Depressive Disorder; Substance P; Antidepressive Agents; Models, Animal; Animals; Humans; Drug Design; Morpholines; Receptors, Neurokinin-1; Clinical Trials as Topic