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Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells.

Abstract:

The transcription factor Runx1 marks all functional hematopoietic stem cells (HSCs) in the embryo and is required for their generation. Mutations in Runx1 are found in approximately 25% of acute leukemias and in familial platelet disorder, suggesting a role for Runx1 in adult hematopoiesis as well. A comprehensive analysis of Runx1 expression in adult hematopoiesis is lacking. Here we show that Runx1 is expressed in functional HSCs in the adult mouse, as well as in cells with spleen colony-fo...

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Publication status:
Published

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Publisher copy:
10.1634/stemcells.22-2-158

Authors


Journal:
Stem cells (Dayton, Ohio)
Volume:
22
Issue:
2
Pages:
158-168
Publication date:
2004-01-01
DOI:
EISSN:
1549-4918
ISSN:
1066-5099
Source identifiers:
325074

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