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RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection.

Abstract:
We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell motility occurred prior to cytokinesis failure. This validation provides a paradigm for the flagellum as a target for future assays and interventions against this human pathogen.
Publication status:
Published

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Publisher copy:
10.1128/ec.00110-07

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Eukaryotic cell More from this journal
Volume:
6
Issue:
7
Pages:
1248-1250
Publication date:
2007-07-01
DOI:
EISSN:
1535-9786
ISSN:
1535-9778
Language:
English
Keywords:
Pubs id:
pubs:2193
UUID:
uuid:ce4add44-063d-45e7-a1e0-914e7a2a2c8c
Local pid:
pubs:2193
Source identifiers:
2193
Deposit date:
2012-12-19

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