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Role for cyclin-dependent kinase 2 in mitosis exit.

Abstract:

Mitosis requires cyclin-dependent kinase (cdk) 1-cyclin B activity [1]. Exit from mitosis depends on the inactivation of the complex by the degradation of cyclin B [2]. Cdk2 is also active during mitosis [3, 4]. In Xenopus egg extracts, cdk2 is primarily in complex with cyclin E, which is stable [5]. At the end of mitosis, downregulation of cdk2-cyclin E activity is accompanied by inhibitory phosphorylation of cdk2 [6]. Here, we show that cdk2-cyclin E activity maintains cdk1-cyclin B during ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
Current biology : CB
Volume:
11
Issue:
15
Pages:
1221-1226
Publication date:
2001-08-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:ce3f2168-b72d-4446-82f6-3db0ec0c3c0c
Source identifiers:
383504
Local pid:
pubs:383504

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