Role for cyclin-dependent kinase 2 in mitosis exit.
Mitosis requires cyclin-dependent kinase (cdk) 1-cyclin B activity . Exit from mitosis depends on the inactivation of the complex by the degradation of cyclin B . Cdk2 is also active during mitosis [3, 4]. In Xenopus egg extracts, cdk2 is primarily in complex with cyclin E, which is stable . At the end of mitosis, downregulation of cdk2-cyclin E activity is accompanied by inhibitory phosphorylation of cdk2 . Here, we show that cdk2-cyclin E activity maintains cdk1-cyclin B during ...Expand abstract
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