Journal article
Role for cyclin-dependent kinase 2 in mitosis exit.
- Abstract:
-
Mitosis requires cyclin-dependent kinase (cdk) 1-cyclin B activity [1]. Exit from mitosis depends on the inactivation of the complex by the degradation of cyclin B [2]. Cdk2 is also active during mitosis [3, 4]. In Xenopus egg extracts, cdk2 is primarily in complex with cyclin E, which is stable [5]. At the end of mitosis, downregulation of cdk2-cyclin E activity is accompanied by inhibitory phosphorylation of cdk2 [6]. Here, we show that cdk2-cyclin E activity maintains cdk1-cyclin B during ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/s0960-9822(01)00352-9
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Bibliographic Details
- Journal:
- Current biology : CB
- Volume:
- 11
- Issue:
- 15
- Pages:
- 1221-1226
- Publication date:
- 2001-08-01
- DOI:
- EISSN:
-
1879-0445
- ISSN:
-
0960-9822
- Source identifiers:
-
383504
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:383504
- UUID:
-
uuid:ce3f2168-b72d-4446-82f6-3db0ec0c3c0c
- Local pid:
- pubs:383504
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2001
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