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Journal article

Dynamic regulation of CD28 conformation and signaling by charged lipids and ions

Abstract:

CD28 provides an essential co-stimulatory signal for T cell activation and its function is critical in antitumor immunity. However, the molecular mechanism of CD28 transmembrane signaling remains elusive. Here, we find that CD28 conformation and signaling are regulated by two counteractive charged factors, i.e. acidic phospholipid and Ca2+ ion. NMR structure shows that acidic phospholipids can sequester CD28 signaling motifs within the membrane, thus limiting CD28 basal signaling. T-cell...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nsmb.3489

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Funding agency for:
Trendel, N
Grant:
Systems Biology DTC
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Funding agency for:
Dushek, O
Grant:
Sir Henry Dale Fellowship (098363
More from this funder
Funding agency for:
Dushek, O
Grant:
Sir Henry Dale Fellowship (098363
Publisher:
Springer Nature Publisher's website
Journal:
Nature Structural and Molecular Biology Journal website
Volume:
24
Pages:
1081–1092
Publication date:
2017-10-23
Acceptance date:
2017-09-21
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Source identifiers:
730233
Pubs id:
pubs:730233
UUID:
uuid:ce3b39a3-ab80-41ab-9e15-f9f573f33c94
Local pid:
pubs:730233
Deposit date:
2017-09-22

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