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Journal article

Dynamic regulation of CD28 conformation and signaling by charged lipids and ions

Abstract:

CD28 provides an essential co-stimulatory signal for T cell activation and its function is critical in antitumor immunity. However, the molecular mechanism of CD28 transmembrane signaling remains elusive. Here, we find that CD28 conformation and signaling are regulated by two counteractive charged factors, i.e. acidic phospholipid and Ca2+ ion. NMR structure shows that acidic phospholipids can sequester CD28 signaling motifs within the membrane, thus limiting CD28 basal signaling. T-cell...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/nsmb.3489

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Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Funding agency for:
Dushek, O
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Funding agency for:
Dushek, O
Publisher:
Springer Nature Publisher's website
Journal:
Nature Structural and Molecular Biology Journal website
Volume:
24
Pages:
1081–1092
Publication date:
2017-10-23
Acceptance date:
2017-09-21
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Pubs id:
pubs:730233
URN:
uri:ce3b39a3-ab80-41ab-9e15-f9f573f33c94
UUID:
uuid:ce3b39a3-ab80-41ab-9e15-f9f573f33c94
Local pid:
pubs:730233

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