Journal article
Dynamic regulation of CD28 conformation and signaling by charged lipids and ions
- Abstract:
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CD28 provides an essential co-stimulatory signal for T cell activation and its function is critical in antitumor immunity. However, the molecular mechanism of CD28 transmembrane signaling remains elusive. Here, we find that CD28 conformation and signaling are regulated by two counteractive charged factors, i.e. acidic phospholipid and Ca2+ ion. NMR structure shows that acidic phospholipids can sequester CD28 signaling motifs within the membrane, thus limiting CD28 basal signaling. T-cell...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
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- Files:
-
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(Accepted manuscript, pdf, 20.7MB)
-
(Accepted manuscript, pdf, 1.2MB)
-
- Publisher copy:
- 10.1038/nsmb.3489
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Authors
Funding
+ Engineering and Physical Science Research Council
More from this funder
Funding agency for:
Trendel, N
Grant:
Systems Biology DTC
+ Wellcome Trust
More from this funder
Funding agency for:
Dushek, O
Grant:
Sir Henry Dale Fellowship (098363
+ Royal Society
More from this funder
Funding agency for:
Dushek, O
Grant:
Sir Henry Dale Fellowship (098363
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Structural and Molecular Biology Journal website
- Volume:
- 24
- Pages:
- 1081–1092
- Publication date:
- 2017-10-23
- Acceptance date:
- 2017-09-21
- DOI:
- EISSN:
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1545-9985
- ISSN:
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1545-9993
- Source identifiers:
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730233
Item Description
- Pubs id:
-
pubs:730233
- UUID:
-
uuid:ce3b39a3-ab80-41ab-9e15-f9f573f33c94
- Local pid:
- pubs:730233
- Deposit date:
- 2017-09-22
Terms of use
- Copyright holder:
- Yang et al
- Copyright date:
- 2017
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/nsmb.3489
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