- Abstract:
-
CD28 provides an essential co-stimulatory signal for T cell activation and its function is critical in antitumor immunity. However, the molecular mechanism of CD28 transmembrane signaling remains elusive. Here, we find that CD28 conformation and signaling are regulated by two counteractive charged factors, i.e. acidic phospholipid and Ca2+ ion. NMR structure shows that acidic phospholipids can sequester CD28 signaling motifs within the membrane, thus limiting CD28 basal signaling. T-cell...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 1.2MB)
-
(pdf, 20.7MB)
-
- Publisher copy:
- 10.1038/nsmb.3489
-
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- Funding agency for:
- Trendel, N
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Structural and Molecular Biology Journal website
- Volume:
- 24
- Pages:
- 1081–1092
- Publication date:
- 2017-10-23
- Acceptance date:
- 2017-09-21
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
- Pubs id:
-
pubs:730233
- URN:
-
uri:ce3b39a3-ab80-41ab-9e15-f9f573f33c94
- UUID:
-
uuid:ce3b39a3-ab80-41ab-9e15-f9f573f33c94
- Local pid:
- pubs:730233
- Copyright holder:
- Yang et al.
- Copyright date:
- 2017
- Notes:
-
This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/nsmb.3489
Journal article
Dynamic regulation of CD28 conformation and signaling by charged lipids and ions
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+ Engineering and Physical Science Research Council
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