Genetic susceptibility to the development of autoimmune disease.

Journal article

1. Autoimmune diseases are common conditions which appear to develop in genetically susceptible individuals, with expression of disease being modified by permissive and protective environments. Familial clustering and data from twin studies provided the impetus for the search for putative loci. Both the candidate gene approach in population-based case-control studies and entire genome screening in families have helped identify susceptibility genes in a number of autoimmune diseases. 2. After ...

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Authors: Heward, J; Gough, S

• Journal: Clinical science (London, England : 1979)
• Volume: 93
• Issue: 6
• Pages: 479-491
• Publication date: 1997-12-01
• EISSN: 1470-8736
• ISSN: 0143-5221
• Language: English
• Keywords: Thyroid Diseases; Diabetes Mellitus, Type 1; Antigens, CD; Disease Susceptibility; Multiple Sclerosis; Arthritis, Rheumatoid; Lupus Erythematosus, Systemic; Genes, MHC Class II; Immunoconjugates; Antigens, Differentiation; Autoimmune Diseases; Insulin; CTLA-4 Antigen; Humans