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The crystal structure of murine leukemia inhibitory factor.

Abstract:

We have determined the structure of murine leukemia inhibitory factor (LIF) by X-ray crystallography at 2.0 A resolution. The current crystal structure comprises native LIF residues 9 to 180 with 40 ordered water molecules. For this model the R value (with a bulk solvent correction) is 18.6% on all data from 20.0 A to 2.0 A with stereochemistry typified by root mean square deviations from ideal bond lengths of 0.015 A. The mainchain fold conforms to the four alpha-helix bundle topology previo...

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Authors


Robinson, RC More by this author
Staunton, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
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Journal:
Annals of the New York Academy of Sciences
Volume:
762
Pages:
179-187
Publication date:
1995-07-05
EISSN:
1749-6632
ISSN:
0077-8923
URN:
uuid:cdfa5631-d830-443e-9575-c812a9c5468b
Source identifiers:
2624
Local pid:
pubs:2624

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