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Biological properties of the venom of the Papuan black snake (Pseudechis papuanus): presence of a phospholipase A2 platelet inhibitor.

Abstract:

The whole venom of Pseudechis papuanus, in addition to its anticoagulant activity, powerfully inhibited platelet aggregation induced by ADP, adrenaline, collagen, ristocetin and thrombin. High levels of phospholipase A2 (PLA2) activity were detected. A mild procoagulant activity was also observed. Following exposure of platelets to P. papuanus venom, platelet factor 3 (procoagulant platelet phospholipid) showed decreased cofactor activity in factor X activation by Russell's viper, venom sugge...

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Publication status:
Published

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Journal:
Toxicon : official journal of the International Society on Toxinology More from this journal
Volume:
32
Issue:
8
Pages:
915-925
Publication date:
1994-08-01
DOI:
EISSN:
1879-3150
ISSN:
0041-0101

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