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A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations.

Abstract:

BACKGROUND: β-Microseminoprotein (MSP) is one of the three most abundantly secreted proteins of the prostate and has been suggested as a biomarker for prostate cancer risk. A common variant, rs10993994, in the 5' region of the gene that encodes MSP (MSMB) has recently been identified as a risk factor for prostate cancer. METHODS: We examined the association between rs10993994 genotype and MSP levels in a sample of 500 prostate cancer-free men from four racial/ethnic populations in the Multiet...

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Journal:
Cancer epidemiology, biomarkers and prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Volume:
19
Issue:
10
Pages:
2639-2646
Publication date:
2010-10-01
DOI:
EISSN:
1538-7755
ISSN:
1055-9965
Source identifiers:
365889
Language:
English
Keywords:
Pubs id:
pubs:365889
UUID:
uuid:cdda3a3b-2b05-4c74-9233-9f66b0fc6b11
Local pid:
pubs:365889
Deposit date:
2013-11-16

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