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In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen.

Abstract:

BACKGROUND: As metastasis is the prime cause of death from malignancies, there is vibrant interest to discover options for the management of the different mechanistic steps of tumour spreading. Some approved pharmaceuticals exhibit activities against diseases they have not been developed for. In order to discover such activities that might attenuate lymph node metastasis, we investigated 225 drugs, which are approved by the US Food and Drug Administration. METHODS: A three-dimensional cell co...

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Publisher copy:
10.1038/bjc.2012.580

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Journal:
British journal of cancer More from this journal
Volume:
108
Issue:
3
Pages:
570-578
Publication date:
2013-02-01
DOI:
EISSN:
1532-1827
ISSN:
0007-0920

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