In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen.

Journal article

BACKGROUND: As metastasis is the prime cause of death from malignancies, there is vibrant interest to discover options for the management of the different mechanistic steps of tumour spreading. Some approved pharmaceuticals exhibit activities against diseases they have not been developed for. In order to discover such activities that might attenuate lymph node metastasis, we investigated 225 drugs, which are approved by the US Food and Drug Administration. METHODS: A three-dimensional cell co...

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Authors: Kretschy, N; Teichmann, M; Kopf, S; Atanasov, A; Saiko, P

• Journal: British journal of cancer
• Volume: 108
• Issue: 3
• Pages: 570-578
• Publication date: 2013-02-01
• DOI: 10.1038/bjc.2012.580
• EISSN: 1532-1827
• ISSN: 0007-0920
• Language: English
• Keywords: Cell Adhesion; Lymphatic Metastasis; Acetohexamide; Tumor Cells, Cultured; Coculture Techniques; Female; Spheroids, Cellular; NF-kappa B; Blotting, Western; Reverse Transcriptase Polymerase Chain Reaction; Chemotaxis; Signal Transduction; Proadifen; Enzyme Inhibitors; Vasodilator Agents; Breast Neoplasms; Nifedipine; Carcinoma, Ductal, Breast; Isoxsuprine; Real-Time Polymerase Chain Reaction; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Lymphatic Vessels; RNA, Messenger; Endothelium, Lymphatic; Cell Movement; Drug Synergism; Hypoglycemic Agents; Humans; Antineoplastic Combined Chemotherapy Protocols