Journal article
Intrinsic neuronal dynamics predict distinct functional roles during working memory
- Abstract:
- Working memory (WM) is characterized by the ability to maintain stable representations over time; however, neural activity associated with WM maintenance can be highly dynamic. We explore whether complex population coding dynamics during WM relate to the intrinsic temporal properties of single neurons in lateral prefrontal cortex (lPFC), the frontal eye fields (FEF) and lateral intraparietal cortex (LIP) of two monkeys (Macaca mulatta). We find that cells with short timescales carry memory information relatively early during memory encoding in lPFC; whereas long timescale cells play a greater role later during processing, dominating coding in the delay period. We also observe a link between functional connectivity at rest and intrinsic timescale in FEF and LIP. Our results indicate that individual differences in the temporal processing capacity predicts complex neuronal dynamics during WM; ranging from rapid dynamic encoding of stimuli to slower, but stable, maintenance of mnemonic information.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.8MB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-018-05961-4
Authors
+ James S McDonnell Foundation Scholar Award
More from this funder
- Funding agency for:
- Stokes, M
- Grant:
- 220020405
- Publisher:
- Springer Nature
- Journal:
- Nature Communications More from this journal
- Volume:
- 9
- Issue:
- 1
- Article number:
- 3499
- Publication date:
- 2018-08-29
- Acceptance date:
- 2018-07-31
- DOI:
- EISSN:
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2041-1723
- Pubs id:
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pubs:896717
- UUID:
-
uuid:cdc94d18-7034-4766-a153-12f4eec0a8a3
- Local pid:
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pubs:896717
- Source identifiers:
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896717
- Deposit date:
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2018-08-07
Terms of use
- Copyright holder:
- Wasmuht et al
- Copyright date:
- 2018
- Notes:
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© The Author(s) 2018. This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as long as you give
appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party
material in this article are included in the article’s Creative Commons license, unless
indicated otherwise in a credit line to the material. If material is not included in the
article’s Creative Commons license and your intended use is not permitted by statutory
regulation or exceeds the permitted use, you will need to obtain permission directly from
the copyright holder. To view a copy of this license, visit http://creativecommons.org/
licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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