- Abstract:
-
Many anticancer therapies, including ionizing radiation (IR), cause cytotoxicity through generation of DNA double-strand breaks (DSB). Delivery of therapeutic radionuclides to DNA DSB sites can amplify this DNA damage, for additional therapeutic gain. Herein, we report on two radiopharmaceuticals, radiolabeled with the Auger electron emitter (111)In, with dual specificity for both the intranuclear, DNA damage repair signaling protein γH2AX and the EGF receptor (EGFR). The EGFR ligand EGF was ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1158/1535-7163.mct-13-0369
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- Publisher:
- American Association for Cancer Research Publisher's website
- Journal:
- Molecular cancer therapeutics Journal website
- Volume:
- 12
- Issue:
- 11
- Pages:
- 2472-2482
- Publication date:
- 2013-11-05
- DOI:
- EISSN:
-
1538-8514
- ISSN:
-
1535-7163
- URN:
-
uuid:cdc2baa5-c9a3-443c-a446-c5b94a38aed7
- Source identifiers:
-
436127
- Local pid:
- pubs:436127
- Language:
- English
- Keywords:
- Copyright holder:
- American Association for Cancer Research
- Copyright date:
- 2013
Journal article
Molecular radiotherapy using cleavable radioimmunoconjugates that target EGFR and γH2AX.
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Cancer Research UK
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CR-UK/EPSRC Cancer Imaging Centre
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Oxford Experimental Cancer Medicine Centre
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