Journal article
Molecular radiotherapy using cleavable radioimmunoconjugates that target EGFR and γH2AX.
- Abstract:
-
Many anticancer therapies, including ionizing radiation (IR), cause cytotoxicity through generation of DNA double-strand breaks (DSB). Delivery of therapeutic radionuclides to DNA DSB sites can amplify this DNA damage, for additional therapeutic gain. Herein, we report on two radiopharmaceuticals, radiolabeled with the Auger electron emitter (111)In, with dual specificity for both the intranuclear, DNA damage repair signaling protein γH2AX and the EGF receptor (EGFR). The EGFR ligand EGF was ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1158/1535-7163.mct-13-0369
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Authors
Funding
CR-UK/EPSRC Cancer Imaging Centre
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Cancer Research UK
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Oxford Experimental Cancer Medicine Centre
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Bibliographic Details
- Publisher:
- American Association for Cancer Research Publisher's website
- Journal:
- Molecular cancer therapeutics Journal website
- Volume:
- 12
- Issue:
- 11
- Pages:
- 2472-2482
- Publication date:
- 2013-11-01
- DOI:
- EISSN:
-
1538-8514
- ISSN:
-
1535-7163
- Source identifiers:
-
436127
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:436127
- UUID:
-
uuid:cdc2baa5-c9a3-443c-a446-c5b94a38aed7
- Local pid:
- pubs:436127
- Deposit date:
- 2013-12-13
Terms of use
- Copyright holder:
- American Association for Cancer Research
- Copyright date:
- 2013
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