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Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration

Abstract:

In the age of stem cell engineering it is critical to understand how stem cell activity is regulated during regeneration. Hairs are mini-organs that undergo cyclic regeneration throughout adult life1, and are an important model for organ regeneration. Hair stem cells located in the follicle bulge2 are regulated by the surrounding microenvironment, or niche3. The activation of such stem cells is cyclic, involving periodic -catenin activity4, 5, 6, 7. In the adult mouse, regeneration occurs in ...

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Publication date:
2008-01-01
URN:
uuid:cdab30d2-f423-4890-8cd6-52bd3ff74bcd
Local pid:
oai:eprints.maths.ox.ac.uk:675

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