Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection.

Conference item

Several inhibitors of the large regulatory enzyme glycogen phosphorylase (GP) have been studied in crystallographic and kinetic experiments. GP catalyses the first step in the phosphorylysis of glycogen to glucose-l-phosphate, which is utilized via glycolysis to provide energy to sustain muscle contraction and in the liver is converted to glucose. alpha-D-Glucose is a weak inhibitor of glycogen phosphorylase form b (GPb, K(i) = 1.7 mM) and acts as a physiological regulator of hepatic glycogen...

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Authors: Watson, K; Mitchell, E; Johnson, L; Cruciani, G; Son, J

• Publication status: Published
• Host title: Acta crystallographica. Section D, Biological crystallography
• Volume: 51
• Issue: Pt 4
• Pages: 458-472
• Publication date: 1995-07-01
• Event location: Denmark
• DOI: 10.1107/s090744499401348x
• EISSN: 1399-0047
• ISSN: 0907-4449