Electrocardiographic safety evaluation of dihydroartemisinin piperaquine in the treatment of uncomplicated falciparum malaria.

Journal article

Dihydroartemisinin-piperaquine (DP) could become a leading fixed combination malaria treatment worldwide. Although there is accumulating evidence of efficacy and safety from clinical trials, data on cardiotoxicity are limited. In two randomized controlled trials in Thailand, 56 patients had ECGs performed before treatment, 4 hours after the first dose, and 4 hours after the last dose. The mean (95% CI) changes in QTc interval (Bazett's correction) were 2 (-6 to 9) ms and 14 (7 to 21) ms, resp...

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Authors: Mytton, O; Ashley, E; Peto, L; Price, R; La, Y

• Publication status: Published
• Journal: American journal of tropical medicine and hygiene
• Volume: 77
• Issue: 3
• Pages: 447-450
• Publication date: 2007-09-01
• EISSN: 1476-1645
• ISSN: 0002-9637
• Language: English
• Keywords: Humans; Arrhythmias, Cardiac; Sesquiterpenes; Malaria, Falciparum; Electrocardiography; Artemisinins