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Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy

Abstract:

Background Androgen-deprivation therapy (ADT) is standard treatment for locally advanced or metastatic prostate cancer (PCa). Many patients develop castration resistance (castration-resistant PCa [CRPC]) after approximately 2-3 yr, with a poor prognosis. The molecular mechanisms underlying CRPC progression are unclear. Objective To undertake quantitative tumour transcriptome profiling prior to and following ADT to identify functionally important androgen-regulated pathways or genes that may b...

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Publisher:
Elsevier
Journal:
European Urology More from this journal
Volume:
66
Issue:
1
Pages:
32-39
Publication date:
2014-01-01
DOI:
EISSN:
1873-7560
ISSN:
0302-2838
Language:
English
Keywords:
Pubs id:
pubs:471764
UUID:
uuid:cd841afc-2a5e-4c4f-8ec6-fca0a7d53cb9
Local pid:
pubs:471764
Source identifiers:
471764
Deposit date:
2014-07-08

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