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Elevated hepcidin at HIV diagnosis is associated with incident tuberculosis in a retrospective cohort study.

Abstract:

Hepcidin inhibits ferroportin-mediated iron efflux, leading to intracellular macrophage iron retention, possibly favoring Mycobacterium tuberculosis iron acquisition and tuberculosis (TB) pathogenesis. Plasma hepcidin was measured at human immunodeficiency virus (HIV) diagnosis in a retrospective HIV-prevalent, antiretroviral-naïve African cohort to investigate the association with incident pulmonary and/or extra-pulmonary TB. One hundred ninety-six participants were followed between 5 August...

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Publication status:
Published

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Publisher copy:
10.5588/ijtld.14.0143

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Publisher:
International Union against Tubercul. and Lung Dis.
Journal:
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Volume:
18
Issue:
11
Pages:
1337-1339
Publication date:
2014-11-05
DOI:
EISSN:
1815-7920
ISSN:
1027-3719
URN:
uuid:cd807e11-643f-4d84-aba8-19a7720385bb
Source identifiers:
487229
Local pid:
pubs:487229
Language:
English
Keywords:

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