Journal article

Elevated hepcidin at HIV diagnosis is associated with incident tuberculosis in a retrospective cohort study.

Abstract:: Hepcidin inhibits ferroportin-mediated iron efflux, leading to intracellular macrophage iron retention, possibly favoring Mycobacterium tuberculosis iron acquisition and tuberculosis (TB) pathogenesis. Plasma hepcidin was measured at human immunodeficiency virus (HIV) diagnosis in a retrospective HIV-prevalent, antiretroviral-naïve African cohort to investigate the association with incident pulmonary and/or extra-pulmonary TB. One hundred ninety-six participants were followed between 5 August 1992 and 1 June 2002, with 32 incident TB cases identified. Greater hepcidin was associated with significantly increased likelihood of TB after a median time to TB of 6 months. Elucidation of iron-related causal mechanisms and time-sensitive biomarkers that identify individual changes in TB risk are needed.

Publication status:: Published

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APA Style

Minchella, P., Armitage, A., Darboe, B., Jallow, M., Drakesmith, H., Jaye, A., Prentice, A., & McDermid, J. (2014). Elevated hepcidin at HIV diagnosis is associated with incident tuberculosis in a retrospective cohort study. International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union against Tuberculosis and Lung Disease, 18(11), 1337–1339.

MLA Style

Minchella, P, et al. “Elevated Hepcidin at HIV Diagnosis Is Associated with Incident Tuberculosis in a Retrospective Cohort Study.” International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union against Tuberculosis and Lung Disease, vol. 18, no. 11, 2014, pp. 1337–39.

Chicago Style

Minchella, P, A Armitage, B Darboe, et al. 2014. “Elevated Hepcidin at HIV Diagnosis Is Associated with Incident Tuberculosis in a Retrospective Cohort Study.” International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union against Tuberculosis and Lung Disease 18 (11): 1337–39.
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Publisher copy:: 10.5588/ijtld.14.0143

Authors

+ Minchella, P More by this author

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+ Armitage, A More by this author

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+ Darboe, B More by this author

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+ Jallow, M More by this author

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+ Drakesmith, H More by this author

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Publisher:: International Union against Tubercul. and Lung Dis.
Journal:: international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease More from this journal
Volume:: 18
Issue:: 11
Pages:: 1337-1339
Publication date:: 2014-11-01
DOI:: 10.5588/ijtld.14.0143
EISSN:: 1815-7920
ISSN:: 1027-3719

Language:: English
Keywords:: biomarker

iron

Africa

inflammation

nutrition
Pubs id:: pubs:487229
UUID:: uuid:cd807e11-643f-4d84-aba8-19a7720385bb
Local pid:: pubs:487229
Source identifiers:: 487229
Deposit date:: 2014-10-22
ARK identifier:: ark:/29072/ora_cd807e11643f4d84aba819a7720385bb

Terms of use

Copyright date:: 2014

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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