Elevated hepcidin at HIV diagnosis is associated with incident tuberculosis in a retrospective cohort study.
Hepcidin inhibits ferroportin-mediated iron efflux, leading to intracellular macrophage iron retention, possibly favoring Mycobacterium tuberculosis iron acquisition and tuberculosis (TB) pathogenesis. Plasma hepcidin was measured at human immunodeficiency virus (HIV) diagnosis in a retrospective HIV-prevalent, antiretroviral-naïve African cohort to investigate the association with incident pulmonary and/or extra-pulmonary TB. One hundred ninety-six participants were followed between 5 August...Expand abstract
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- International Union against Tubercul. and Lung Dis.
- international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
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