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Journal article

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Abstract:

To dissect the genetic architecture of blood pressure (BP) and assess how its elevation promotes downstream cardiovascular diseases, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry. Genotypes from an additional 140,886 individuals of European ancestry were used as validation for loci reaching genome-wide significance but without prior support in the literature. We identified 66 BP loci, of which 17 were novel and 15 harbored multipl...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/ng.3667

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Strategic
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
48
Pages:
1171–1184
Publication date:
2016-09-05
Acceptance date:
2016-07-18
DOI:
ISSN:
1546-1718
URN:
uuid:cd78c01c-ad6c-4c2e-8a63-72770b4b150f
Source identifiers:
634559
Local pid:
pubs:634559

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