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Meiotic defects in the Arabidopsis rad50 mutant point to conservation of the MRX complex function in early stages of meiotic recombination.

Abstract:

The Rad50, Mre11 and Xrs2/Nbs1 proteins, which form the highly conserved MRX complex, perform a wide range of functions concerning the maintenance and function of DNA in eukaryotes. These include recombination, DNA repair, replication, telomere homeostasis and meiosis. Notwithstanding the attention paid to this complex, the inviability of vertebrate rad50 and mre11 mutants has led to a relative lack of information concerning the role of these proteins in meiosis in higher eukaryotes. We have ...

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Publisher copy:
10.1007/s00412-004-0309-1

Authors


Journal:
Chromosoma
Volume:
113
Issue:
4
Pages:
197-203
Publication date:
2004-10-05
DOI:
EISSN:
1432-0886
ISSN:
0009-5915
URN:
uuid:cd7688f8-ceab-4ca7-a1b8-17e5e75a23c2
Source identifiers:
55295
Local pid:
pubs:55295

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