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Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection.

Abstract:

Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses generated during acute infection play a critical role in the initial control of viremia. However, little is known about the viral T-cell epitopes targeted during acute infection or about their hierarchy in appearance and relative immunodominance over time. In this study, HIV-1-specific CD8+ T-cell responses in 18 acutely infected individuals expressing HLA-A3 and/or -B7 were characterized. Detailed analysis of CD8 resp...

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Journal:
Journal of virology More from this journal
Volume:
76
Issue:
17
Pages:
8690-8701
Publication date:
2002-09-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:191090
UUID:
uuid:cd71ee20-b5e1-438c-af44-d6dfa1b90434
Local pid:
pubs:191090
Source identifiers:
191090
Deposit date:
2012-12-19

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