Journal article
Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic.
- Abstract:
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Localized clustering of damage is a hallmark of certain DNA-damaging agents, particularly ionizing radiation. The potential for genetic change arising from the effects of clustered damage sites containing combinations of AP sites, 8-oxo-7,8-dihydroguanine (8-oxoG) or 5,6-dihydrothymine is high. To date clusters containing a DNA base lesion that is a strong block to replicative polymerases, have not been explored. Since thymine glycol (Tg) is non-mutagenic but a strong block to replicative pol...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.4MB)
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- Publisher copy:
- 10.1093/nar/gkp422
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Authors
Funding
Medical Research Council
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic acids research Journal website
- Volume:
- 37
- Issue:
- 13
- Pages:
- 4430-4440
- Publication date:
- 2009-07-01
- DOI:
- EISSN:
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1362-4962
- ISSN:
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0305-1048
- Source identifiers:
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130858
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:cd6cd2b4-1355-45aa-bb2f-0a02cc8dfdb4
- Local pid:
- pubs:130858
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Bellon et al
- Copyright date:
- 2009
- Notes:
- Copyright © 2009 Bellon et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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