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Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic.

Abstract:

Localized clustering of damage is a hallmark of certain DNA-damaging agents, particularly ionizing radiation. The potential for genetic change arising from the effects of clustered damage sites containing combinations of AP sites, 8-oxo-7,8-dihydroguanine (8-oxoG) or 5,6-dihydrothymine is high. To date clusters containing a DNA base lesion that is a strong block to replicative polymerases, have not been explored. Since thymine glycol (Tg) is non-mutagenic but a strong block to replicative pol...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gkp422

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Medical Research Council More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
37
Issue:
13
Pages:
4430-4440
Publication date:
2009-07-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Source identifiers:
130858
Language:
English
Keywords:
UUID:
uuid:cd6cd2b4-1355-45aa-bb2f-0a02cc8dfdb4
Local pid:
pubs:130858
Deposit date:
2012-12-19

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