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Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties.

Abstract:

Mammalian CD98 heterodimeric amino acid transporters consist of a promiscuous single-pass transmembrane glycoprotein, CD98hc (CD98 heavy chain), and one of six multipass transmembrane proteins or 'light chains'. The heterodimeric complexes of CD98hc and the light chains LAT1 (L-type amino acid transporter 1) or LAT2 specifically promote sodium-independent System L exchange of neutral amino acids, including leucine. CD98hc is also implicated in other processes, including cell fusion, cell adhe...

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Publication status:
Published

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Publisher copy:
10.1042/bj20082198

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Biochemical journal More from this journal
Volume:
420
Issue:
3
Pages:
363-372
Publication date:
2009-06-01
DOI:
EISSN:
1470-8728
ISSN:
0264-6021

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