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Characterization of the fine specificity of bovine CD8 T-cell responses to defined antigens from the protozoan parasite Theileria parva.

Abstract:

Immunity against the bovine intracellular protozoan parasite Theileria parva has been shown to be mediated by CD8 T cells. Six antigens targeted by CD8 T cells from T. parva-immune cattle of different major histocompatibility complex (MHC) genotypes have been identified, raising the prospect of developing a subunit vaccine. To facilitate further dissection of the specificity of protective CD8 T-cell responses and to assist in the assessment of responses to vaccination, we set out to identify ...

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Publication status:
Published

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Publisher copy:
10.1128/iai.01244-07

Authors


Graham, SP More by this author
Mwangi, DM More by this author
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Journal:
Infection and immunity
Volume:
76
Issue:
2
Pages:
685-694
Publication date:
2008-02-05
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:cd52a113-54a5-4e55-b90e-a1f4f12d0e41
Source identifiers:
40606
Local pid:
pubs:40606

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