Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson’s disease

Journal article

Parkinson's disease is the most common neurodegenerative disease. Until recently, the treatment was focused on dopamine deficiency and enabling patient activity. Much less attention was paid to the cognitive impairment and non-motor symptoms of the disease. Dementia, hallucinations and delusions are the most common cognitive disorder influencing a patient's quality of life. Hallucinations are probably the most common and bothersome non-motoric symptom. This paper discusses the diagnosis and treatment of hallucinations with atypical antipsychotics and possible alternatives. We also suggest a sensible approach for patients with hallucinations and delusions

Authors: Zarkali, A; Luppi, AI; Stamatakis, EA; Reeves, S; McColgan, P

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Communications Biology
• Volume: 5
• Issue: 1
• Pages: 928-928
• Publication date: 2022-09-08
• DOI: 10.1038/s42003-022-03903-x
• EISSN: 2399-3642
• ISSN: 2399-3642
• Language: English
• Keywords: Serotonin; Dopaminergic; Internal medicine; Psychology; Sensory processing; Inhibitory postsynaptic potential; Serotonergic; Neuroscience; Neurotransmitter receptor; Psychosis; Biology; Medicine; Neurochemistry; Disease; Neurotransmitter; GABAergic; Psychiatry; Central nervous system; Parkinson's disease; Dopamine; Neurology; Receptor; Sensory system