Journal article
Control of PTH secretion by the TRPC1 ion channel
- Abstract:
-
Familial Hypocalciuric Hypercalcemia (FHH) is a genetic condition associated with hypocalciuria, hypercalcemia and in some cases inappropriately high levels of circulating parathyroid hormone (PTH). FHH is associated with inactivating mutations in CaSR encoding the Ca2+ sensing receptor (CaSR), a G protein coupled receptor (GPCR) and GNA11 encoding G protein subunit alpha 11 (Gα11), implicating defective GPCR signaling as the root pathophysiology for FHH. However, the downstream mechanism by ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Contributors
+ Stevenson, M
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Contributor
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- JCI insight Journal website
- Volume:
- 5
- Issue:
- 8
- Article number:
- e132496
- Publication date:
- 2020-03-26
- Acceptance date:
- 2020-03-16
- DOI:
- EISSN:
-
2379-3708
- ISSN:
-
2379-3708
- Pmid:
-
32213715
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1099239
- Local pid:
- pubs:1099239
- Deposit date:
- 2020-04-15
Terms of use
- Copyright holder:
- American Society for Clinical Investigation
- Copyright date:
- 2020
- Rights statement:
- © 2020, Onopiuk et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License
- Licence:
- CC Attribution (CC BY)
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