Substitution rates in the X- and Y-linked genes of the plants, Silene latifolia and S. dioica.

Filatov, D; Charlesworth, D

Journal article

Substitution rates in the X- and Y-linked genes of the plants, Silene latifolia and S. dioica.

Abstract:: Theory predicts that selection should be less effective in the nonrecombining genes of Y-chromosomes, relative to the situation for genes on the other chromosomes, and this should lead to the accumulation of deleterious nonsynonymous substitutions. In addition, synonymous substitution rates may differ between X- and Y-linked genes because of the male-driven evolution effect and also because of actual differences in per-replication mutation rates between the sex chromosomes. Here, we report the first study of synonymous and nonsynonymous substitution rates on plant sex chromosomes. We sequenced two pairs of sex-linked genes, SlX1-SlY1 and SlX4-SlY4, from dioecious Silene latifolia and S. dioica, and their non-sex-linked homologues from nondioecious S. vulgaris and Lychnis flos-jovis, respectively. The rate of nonsynonymous substitutions in the SlY4 gene is significantly higher than that in the SlX4 gene. Silent substitution rates are also significantly higher in both Y-linked genes, compared with their X-linked homologues. The higher nonsynonymous substitution rate in the SlY4 gene is therefore likely to be caused by a mutation rate difference between the sex chromosomes. The difference in silent substitution rates between the SlX4 and SlY4 genes is too great to be explained solely by a higher per-generation mutation rate in males than females. It is thus probably caused by a difference in per-replication mutation rates between the sex chromosomes. This suggests that the local mutation rate can change in a relatively short evolutionary time.

Publication status:: Published

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APA Style

Filatov, D., & Charlesworth, D. (2002). Substitution rates in the X- and Y-linked genes of the plants, Silene latifolia and S. dioica. Molecular Biology and Evolution, 19(6), 898–907.

MLA Style

Filatov, D., and D. Charlesworth. “Substitution Rates in the X- and Y-Linked Genes of the Plants, Silene Latifolia and S. Dioica.” Molecular Biology and Evolution, vol. 19, no. 6, 2002, pp. 898–907.

Chicago Style

Filatov, D, and D Charlesworth. 2002. “Substitution Rates in the X- and Y-Linked Genes of the Plants, Silene Latifolia and S. Dioica.” Molecular Biology and Evolution 19 (6): 898–907.
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