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Journal article : Letter

A lower X-gate in TASK channels traps inhibitors within the vestibule

Abstract:

TWIK-related acid-sensitive potassium (TASK) channels—members of the two pore domain potassium (K2P) channel family—are found in neurons1, cardiomyocytes2,3,4 and vascular smooth muscle cells5, where they are involved in the regulation of heart rate6, pulmonary artery tone5,7, sleep/wake cycles8 and responses to volatile anaesthetics8,9,10,11. K2P channels regulate the resting membrane potential, providing background K+ currents controlled by numerous physiological stimuli12,13,14,15. Unlike ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1038/s41586-020-2250-8

Authors


More from this funder
Name:
Wellcome Trust
Grant:
106169/Z/14/Z
More from this funder
Name:
European Commission
Grant:
115766
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/N009274/1
BB/N009274/1
Publisher:
Nature Research
Journal:
Nature More from this journal
Volume:
582
Issue:
7812
Pages:
443-450
Publication date:
2020-04-29
Acceptance date:
2020-03-12
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Language:
English
Keywords:
Subtype:
Letter
Pubs id:
1097771
Local pid:
pubs:1097771
Deposit date:
2020-03-31

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