G6PD deficiency: global distribution, genetic variants and primaquine therapy.

Journal article

Glucose-6-phosphate dehydrogenase (G6PD) is a potentially pathogenic inherited enzyme abnormality and, similar to other human red blood cell polymorphisms, is particularly prevalent in historically malaria endemic countries. The spatial extent of Plasmodium vivax malaria overlaps widely with that of G6PD deficiency; unfortunately the only drug licensed for the radical cure and relapse prevention of P. vivax, primaquine, can trigger severe haemolytic anaemia in G6PD deficient individuals. This...

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Authors: Howes, R; Battle, K; Satyagraha, A; Baird, J; Hay, S

• Publication status: Published
• Journal: Advances in parasitology
• Volume: 81
• Pages: 133-201
• Publication date: 2013-01-01
• DOI: 10.1016/b978-0-12-407826-0.00004-7
• ISSN: 0065-308X
• Language: English
• Keywords: Primaquine; Malaria, Vivax; Mutation; Antimalarials; Humans; Glucosephosphate Dehydrogenase Deficiency; Prevalence