- Abstract:
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Despite the advent of tyrosine kinase inhibitors, a proportion of chronic myeloid leukemia patients in chronic phase fails to respond to Imatinib or to second generation inhibitors and progress to blast crisis. Limited improvements in the understanding of the molecular mechanisms responsible for chronic myeloid leukemia transformation from chronic phase to the aggressive blast crisis were achieved until now. We present here a massive parallel sequencing analysis of 10 blast crisis samples and...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 1.9MB)
-
- Publisher copy:
- 10.3324/haematol.2017.179937
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- Publisher:
- Ferrata Storti Foundation Publisher's website
- Journal:
- Haematologica Journal website
- Volume:
- 104
- Issue:
- 9
- Pages:
- 1789-1797
- Publication date:
- 2019-02-28
- Acceptance date:
- 2019-02-26
- DOI:
- EISSN:
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1592-8721
- ISSN:
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0390-6078
- Pubs id:
-
pubs:890224
- URN:
-
uri:ccea9dc3-7f15-4191-b888-d0badab601e4
- UUID:
-
uuid:ccea9dc3-7f15-4191-b888-d0badab601e4
- Local pid:
- pubs:890224
- Keywords:
- Copyright holder:
- Ferrata Storti Foundation
- Copyright date:
- 2019
- Notes:
- © 2019 Ferrata Storti Foundation. Material published in Haematologica is covered by copyright. All rights are reserved to the Ferrata Storti Foundation. Use of published material is allowed under the following terms and conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode. Copies of published material are allowed for personal or internal use. Sharing published material for non-commercial purposes is subject to the following conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode, sect. 3. Reproducing and sharing published material for commercial purposes is not allowed without permission in writing from the publisher.
Journal article
De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways
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