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De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways

Abstract:

Despite the advent of tyrosine kinase inhibitors, a proportion of chronic myeloid leukemia patients in chronic phase fails to respond to Imatinib or to second generation inhibitors and progress to blast crisis. Limited improvements in the understanding of the molecular mechanisms responsible for chronic myeloid leukemia transformation from chronic phase to the aggressive blast crisis were achieved until now. We present here a massive parallel sequencing analysis of 10 blast crisis samples and...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.3324/haematol.2017.179937

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Publisher:
Ferrata Storti Foundation Publisher's website
Journal:
Haematologica Journal website
Volume:
104
Issue:
9
Pages:
1789-1797
Publication date:
2019-02-28
Acceptance date:
2019-02-26
DOI:
EISSN:
1592-8721
ISSN:
0390-6078
Pubs id:
pubs:890224
URN:
uri:ccea9dc3-7f15-4191-b888-d0badab601e4
UUID:
uuid:ccea9dc3-7f15-4191-b888-d0badab601e4
Local pid:
pubs:890224
Keywords:

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