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Structural basis for complement factor I control and its disease-associated sequence polymorphisms

Abstract:

The complement system is a key component of innate and adaptive immune responses. Complement regulation is critical for prevention and control of disease. We have determined the crystal structure of the complement regulatory enzyme human factor I (fI). FI is in a proteolytically inactive form, demonstrating that it circulates in a zymogen-like state despite being fully processed to the mature sequence. Mapping of functional data from mutants of fI onto the structure suggests that this inactiv...

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Publisher copy:
10.1073/pnas.1102167108

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Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
108
Issue:
31
Pages:
12839-12844
Publication date:
2011-08-02
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:179248
UUID:
uuid:cce72750-7f3c-4170-b8f2-4ef57f8e57e9
Local pid:
pubs:179248
Source identifiers:
179248
Deposit date:
2013-11-16

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