Journal article icon

Journal article

Homology modelling of human P-glycoprotein.

Abstract:

P-glycoprotein (P-gp) is an ATP-binding cassette transporter that exports a huge range of compounds out of cells and is thus one of the key proteins in conferring multi-drug resistance in cancer. Understanding how it achieves such a broad specificity and the series of conformational changes that allow export to occur form major, on-going, research objectives around the world. Much of our knowledge to date has been derived from mutagenesis and assay data. However, in recent years, there has als...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1042/bst20150125

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Publisher:
Portland Press
Journal:
Biochemical Society transactions More from this journal
Volume:
43
Issue:
5
Pages:
952-958
Publication date:
2015-10-01
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
Language:
English
Keywords:
Pubs id:
pubs:575219
UUID:
uuid:ccd1b0ce-e326-4c13-a7cf-a147c5cca18b
Local pid:
info:fedora/pubs:575219
Source identifiers:
575219
Deposit date:
2016-03-14

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP