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The luminal Ca(2+) chelator, TPEN, inhibits NAADP-induced Ca(2+) release.

Abstract:

The regulation of Ca(2+) release by luminal Ca(2+) has been well studied for the ryanodine and IP(3) receptors but has been less clear for the NAADP-regulated channel. In view of conflicting reports, we have re-examined the issue by manipulating luminal Ca(2+) with the membrane-permeant, low affinity Ca(2+) buffer, TPEN, and monitoring NAADP-induced Ca(2+) release in sea urchin egg homogenate. NAADP-induced Ca(2+) release was almost entirely blocked by TPEN (IC(50) 17-25μM) which suppressed t...

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Publication status:
Published

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Publisher copy:
10.1016/j.ceca.2012.09.001

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Cell calcium More from this journal
Volume:
52
Issue:
6
Pages:
481-487
Publication date:
2012-12-01
DOI:
EISSN:
1532-1991
ISSN:
0143-4160
Language:
English
Keywords:
Pubs id:
pubs:356299
UUID:
uuid:ccccb26a-f643-4bc2-9e4e-e13c4180fe52
Local pid:
pubs:356299
Source identifiers:
356299
Deposit date:
2013-11-16

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