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The human side of hypoxia-inducible factor.

Abstract:

When humans are exposed to hypoxia, systemic and intracellular changes operate together to minimise hypoxic injury and restore adequate oxygenation. Emerging evidence indicates that the hypoxia-inducible factor (HIF) family of transcription factors plays a central regulatory role in these homeostatic changes at both the systemic and cellular levels. HIF was discovered through its action as the transcriptional activator of erythropoietin, and has subsequently been found to control intracellula...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Role:
Author
Journal:
British journal of haematology
Volume:
141
Issue:
3
Pages:
325-334
Publication date:
2008-05-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:ccc4e26e-239d-4fa9-9959-e84c1de0bc2e
Source identifiers:
17861
Local pid:
pubs:17861

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